P.O. Box 12564 • RTP NC 27709 • TEL 919-544-0065 • FAX 919-572-9288 • EMAIL chemistry@customsynthesis.com



Catalog of unique and/or rare piperidines, piperazines, diazabicyclo's, pyrrolidines & more                         Name Reactions List

High priority & Special Synthesis Projects


Novel Drug Prototypes
Scaled Intermediates (scaffolds)
Reference Standards
Process Chemistry
Small Focused Libraries (10 - 100 compounds)
Organic Materials for Solar Cells & Transistors
Fluorophores & Light Emitting Polymeric Organics



NMR Station


Purification Station 313A


Typical 5L Reaction



Typical 22 L Reaction



Benefits of Smaller CRO


Highly Focused Chemists
Projects Completed Faster
Lower Cost For High Quality Work
High Quality Output
No Effort Dilution


Chemical Development & Optimization

Large & Small Scale
Design of New Procedures
New Polymorphs & Analysis
Patent Experimental Validation


Custom Building Block Examples


Piperazine Amino Acid Production
Custom Orthogonal Protection Strategies



Piperidine α Amino Acids
Click structure for other examples



Pyrrolidine α Amino Acids
Click structure for other examples



Unnatural-αα-disubstituted Amino Acids
Suitably protected for Protein Engineering




Rapid-Turnaround Synthesis

Projects Commence in 24-48 hrs
Quotations in 24 hrs
Known & Unknown Compounds
Most Competitive Rates
Result Driven

Est. 1997 in Research Triangle Park, NC




Experience and Cost Containment

Many larger " impressive companys" can be
costly and less efficient. Frequently the chemists
are inundated with multiple projects causing
a dilution of attention and focus needed for
successful outcomes.

MonomerChem Inc has a long history of:


•No disappointing teleconferences
•No disappointing reports
•No excuses
•Just results

This is because Monomerchem Chemists have
all been trained by large pharma (Pfizer, Glaxo &
Burroughs Wellcome) and have routinely synthesized
and purified a vast array of both novel and known
compounds.


NON PROPRIETARY EXAMPLES
(click on structure for details)


(+)-9-O-Desmethyl-α-dihydrotetrabenazine



2'-Fl-2'-deoxy-Nicotinamide
Arabino mononucleotide


Nonproprietary improved multi-gram prep
by Custom Synthesis Inc


SR 141716 constrained analogs

Improved multi-gram prep
by MonomerChem Inc


Ibudilast combi-chem scaffold

Example of a large scale preparation
of high energy intermediates




Novel Analogs of Reference Stds

New TAK-536 analogs
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Over 14 Years Serving The Pharmaceutical,
BioTech, & Electronic Engineering Industries including:

•Major Universities
•Major Pharmaceutical Companies
•Major Engineering Companies
•Federal Agencies
•BioTech Start-Ups










P.O. Box 12564 • RTP NC 27709 • TEL 919-544-0065 • FAX 919-572-9288 • EMAIL chemistry@customsynthesis.com